According to the "China News" report of Voice of China, for a long time, China's AIDS treatment drugs are imported products, there is no independent research and development of new anti-AIDS drugs, but the clinical demand for new anti-AIDS drugs is growing. Yesterday (13th), the reporter learned from the State Administration of Drug Administration that China's self-developed new anti-AIDS drug, Abbott Thai long-acting injection was approved for marketing.

This is China's first long-term anti-AIDS fusion inhibitor and has global original intellectual property rights. The listing of this drug shows that China's anti-AIDS drugs have achieved a zero breakthrough. So, what changes will this bring to the treatment of people living with HIV?

AIDS is a major infectious disease in the field of public health. For a long time, China's AIDS treatment drugs have relied on imports, and there are no new anti-AIDS drugs independently developed, but the demand for new clinical anti-AIDS drugs is growing. For early AIDS patients who have been using drug treatment for many years, drug resistance is inevitable Sex. Zhao Jianzhong, a reviewer of the Second Department of Clinical Medicine of the National Drug Administration, said that the listing of the drug not only provides life-saving drugs for the clinical treatment of AIDS-resistant patients, but also provides patients with other intolerant adverse reactions. New options. The previous medicine was used twice a day, and the local adverse reactions were relatively serious. This time the medicine has changed a lot, the effect is very long, only need to be administered once a week. And from the existing data, the efficacy and safety are also very good, the drug can provide a new method for AIDS treatment.

As of the end of September last year, there were 747,000 people living with HIV in the country. Since 2004, China has issued free medicines for the treatment of AIDS patients. However, the domestically produced generic drugs at that time were not fully applicable to Chinese physiques, and had toxic and side effects. Li Taisheng, a well-known AIDS clinical expert and director of the Peking Union Medical College Hospital's Infection Department, repeatedly compared the effects of various drug treatments, and finally optimized two programs for promotion nationwide.

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Since then, China has been using anti-aimon treatment programs based on domestic generic drugs. The efficacy is equivalent to imported drugs, but the price is only one-sixth of imported drugs. It is particularly worth noting that the approved Abbott Thai long-acting injection is not a generic drug, but an original researched and developed drug with independent intellectual property rights. Li Taisheng said that this is the first class of new drugs with Chinese independent intellectual property rights and the world ’s first long-acting fusion inhibitor. "The so-called long-term effect is to administer an injection tube for a week, usually once or twice a day. From a clinical perspective, this adds a new option for doctors and patients."

In December 2017, the former State Food and Drug Administration issued and implemented the "Opinions on Encouraging Priority Review and Approval of Drug Innovation", pointing out that applications for the registration of AIDS prevention and treatment drugs can be included in the scope of priority review and approval. In order to improve the quality and speed of the drug's evaluation, the National Drug Administration's Drug Evaluation Center has developed a Phase III clinical evaluation standard for companies in accordance with international practice, and has given guidance on how to carry out clinical trials. Wang Tao, chief reviewer of the Drug Evaluation Center of the State Food and Drug Administration, said that while encouraging the domestic innovative drugs to be clinically researched and developed, China will also introduce drugs that are already on the market in developed countries in the world to China as soon as possible to solve Medication needs. (Reporter Che Li)

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