Recently, the research team led by Qin Jianhua, a researcher at the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, has made new progress in the use of microfluidic technology to biomimetically synthesize functionalized micron-fiber biomaterials. Research results are published in the latest Advanced Materials (2014, 26). , 2494–2499) on. In the natural world, the shape and structure of bamboo is tough and upright, and it is well-distributed. It is called one of the four gentlemen of "Mei Lan Zhu Ju". The research work skillfully utilized droplet microfluidics and wet spinning principles. For the first time, a bionic design was developed to prepare a novel bionic hybrid fiber material with an orderly array of fiber-microspheres and an exquisite "bamboo" pattern. Explore the potential applications of its biological functions. The fiber material prepared by this work has a diameter of about 100-200 μm and a length of up to several tens of meters. It uses a natural hydrogel with biocompatibility as a "bamboo rod", and the spherical materials arranged in an orderly manner are dehydrated to form a " "Bamboo", in which the spherical structure material may be a high molecular polymer, micro-droplets, or even biologically active cell microspheres. The remarkable feature of this preparation method is that spherical materials can be arranged inside the microfibers through a digital microfluidic system and can be controlled and coded, and give this fiber material extremely flexible biological functional properties. This new type of hybrid microfiber material can be used as a functional carrier for many types of cells and biomolecules. The material can be loaded on the surface and inside of different types of cells. It can be used not only as a reactor for large-scale culture and expansion of stem cells, but also as a kind of The transitional space scaffold material forms a three-dimensional tissue or is used for transplantation therapy, and has important application prospects in the field of tissue engineering and regenerative medicine. In the past two years, the Dalian Institute of Microfluidic Chip Research Group has carried out a series of new biomaterial synthesis, biological interface biomimetic and biomedical application research based on the integration of microfluidic chip and nano-bio-integration technology, and has made remarkable progress. Some of the results were published in Biomaterials (2014, 35, 1390-1401), Integrative Biology (2014, 6, 35-43), Small (2013, 9, 497–503), Nanoscale (2013, 5, 4687-4690), Advanced Materials, respectively. (2012, 24, 2191-2195) and so on. The above work was supported by the National Natural Science Foundation of China and the important directional projects of the Knowledge Innovation Project of the Chinese Academy of Sciences.
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